The necessary of ternary amyloid classification for clinical practice: An alternative to the binary amyloid definition

Visual interpretation is considered the gold standard for amyloid scans in clinical practice. However, dichotomous classification of deposition by visual reading always results bias due to rater experience. Therefore, there a need more lenient and flexible amyloid-equivocal A total 461 participants were included this study. Amyloid glucose positron-emission tomography was performed, neuropsychological tests evaluated. disease-specific deep-learning method used identify equivocality. deposition, metabolism, cognitive performance analyzed compared among amyloid-positive, amyloid-negative, groups. Clinically diagnosed Alzheimer's disease individuals subjects with normal cognition create biomarker cut points support definition equivocal deposition. 139 identified deep learning methods. They displayed intermediate between that amyloid-positive (standardized uptake value ratio [SUVr]: 1.25 ± 0.10 vs. 1.47 0.20, p < 0.001) amyloid-negative (SUVr: 1.18 0.07, individuals. No difference metabolism or observed negativity Furthermore, SUVr whole cortex, precuneus, frontal lobe served as auxiliary criteria supporting diagnosis We also established guide assist equivocality including two